Memory Generation and Re-Activation in Food Allergy
نویسندگان
چکیده
Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these as therapeutic targets. IgG+ B replenish pools IgE-secreting upon allergen exposure, which contract thereafter due to short lifespan tightly regulated IgE-expressing cells. Advances detection and highly dimensional analysis allergen-specific T from allergic patients have provided insight on their phenotype function. The newly identified Th2A Tfh13 populations represent a leap our understanding cell phenotypes, although how contribute IgE responses remains poorly understood. Within, we discuss mechanisms by are activated, integrating knowledge human systems fundamental research. We then focus reactivation, specifically, pathways secondary responses. Throughout, identify areas future research will help immunotargets for transformative therapy allergy.
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ژورنال
عنوان ژورنال: ImmunoTargets and therapy
سال: 2021
ISSN: ['2253-1556']
DOI: https://doi.org/10.2147/itt.s284823